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spots supplements/HMB

spots supplements/HMB

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-Hydroxy -methylbutyric acid (HMB), or -hydroxy -methylbutyrate, is a of the and is synthesized in the . It plays a part in and was discovered by Dr. Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. However, Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pig breast milk and small quantities can also be found in , , and . As a supplement it is usually sold as a calcium salt.
Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research. The same study lists as HMBs proposed the following:
Increased integrity via conversion to
Enhanced protein synthesis via the
Depression of through inhibition of the pathway
Three grams of HMB per day may help muscles combat protein breakdown, assist in muscle repair and support increased endurance. Studies suggest its benefits may be greater for the untrained. Also, well-controlled scientific studies have found increases in muscle mass and decreases in body fat in 70 year old men. It has helped patients with in hospital intensive care units, muscle wasting associated with or and with , and trauma victims with severe injuries.[]
The human body produces about 0.2-0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses.


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