Fursultiamine

About Fursultiamine

 Name: Fursultiamine
Synonyms:N-(4-Amino-2-methylpyrimidin-5-ylmethyl)-N-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamide
Molecular Formula:C17H26N4O3S2
Molecular Weight:398.55
CAS Registry Number:804-30-8
EINECS: 212-357-1
 
Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis
Object and design: The therapeutic effect of glucosamine hydrochloride (GH) and chondroitin sulfate (CS) in combination with fursultiamine, a vitamin B 1 derivative, on the development of cartilage lesions was investigated in an animal model of osteoarthritis (OA). Methods: The OA model was created by partial medial meniscectomy of the right knee joint (day 0). The rabbits were placed into three experimental groups: operated (OA) rabbits that received placebo treatment, OA rabbits that received GH (1000 mg/kg) + CS (800 mg/kg), and OA rabbits that received GH + CS + fursultiamine (100 mg/kg). Each treatment was initiated on day 3 and continued for 8 weeks. Macroscopic and histologic analyses were performed on the cartilage. The level of MMP-1 in OA cartilage chondrocytes was evaluated by immunohistochemistry. Results: Only the group receiving combined treatment with GH + CS + fursultiamine showed a significant reduction in the severity of macroscopic and histologic lesions on tibial plateau, which is the weight bearing cartilage surface of the tibia, compared with placebo-treated OA rabbits. This treatment group also revealed a small, but significant, decrease in the body weight gain of the rabbits. In cartilage from placebo-treated OA rabbits, a significantly higher percentage of chondrocytes in superficial layer stained positive for MMP-1 compared with unoperated control. Rabbits treated with the GH + CS + fursultiamine revealed a significant reduction in the level of MMP-1. Conclusion: These results suggest that the chondroprotective effect of GH + CS is enhanced by the addition of fursultiamine in experimental OA. This effect was associated with a reduction in the level of MMP-1, which are known to play an important role in the pathophysiology of OA lesions
 

Enhance Thiamine Absorption and Neurological Health

Fursultiamine is expertly formulated to improve vitamin B1 uptake, effectively elevating blood thiamine levels and optimizing nerve function. As a pharmaceutical-grade supplement, it plays a vital role in preventing and treating B1 deficiency, supporting neurological health, and maintaining overall cognitive performance. Its rapid absorption profile makes it a preferred choice for both dietary supplementation and therapeutic uses.


Pharmaceutical Purity and Reliable Sourcing

Manufactured in Japan and supplied in China, Fursultiamine strictly adheres to pharmaceutical-grade standards and boasts a purity of