guaiacol

Product Description

Guaiacol Basic information
Product Name: Guaiacol
Synonyms: PYROCATECHOL MONOMETHYL ETHER;PYROGUAIAC ACID;O-METHOXYPHENOL;O-METHYLCATECHOL;O-HYDROXYANISOLE;CATECHOL MONOMETHYL ETHER;Gulaiacol;GUAJACOL
CAS: 90-05-1
MF: C7H8O2
MW: 124.14
EINECS: 201-964-7
Product Categories: Pharmaceutical Intermediates;Aromatic Ethers;Aromatics Compounds;Antioxidant;Biochemistry;Aromatics
Mol File: 90-05-1.mol
 

 
Guaiacol Chemical Properties
mp  26-29 °C(lit.)
 
bp  205 °C(lit.)
 
density  1.129 g/mL at 25 °C(lit.)
 
vapor density  4.27 (vs air)
 
vapor pressure  0.11 mm Hg ( 25 °C)
 
refractive index  n20/D 1.543(lit.)
 
FEMA  2532
Fp  180 °F
 
Water Solubility  17 g/L (15 oC)
FreezingPoint  28°C
Sensitive  Air Sensitive
Merck  14,4553
BRN  508112
Stability: Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference 90-05-1(CAS DataBase Reference)
NIST Chemistry Reference Phenol, 2-methoxy-(90-05-1)
EPA Substance Registry System Phenol, 2-methoxy-(90-05-1)

 
Safety Information
Hazard Codes  Xn,T,Xi
Risk Statements  22-36/38
Safety Statements  26
RIDADR  2810
WGK Germany  1
 
RTECS  SL7525000
 
Hazard Note  Toxic/Irritant
HazardClass  6.1(b)
PackingGroup  II
HS Code  29095010
Hazardous Substances Data 90-05-1(Hazardous Substances Data)

 
MSDS Information 

Provider Language
1-Hydroxy-2-methoxybenzene  English
SigmaAldrich  English
ACROS  English
ALFA  English

 
Guaiacol Usage And Synthesis
Chemical Properties Light Yellow Oil
General Description Colorless to amber crystals or liquid. Density (of solid) 1.129 g / cm3. Solidifies at 28°C (82.4°F), but may remain liquid for a long time even at a much lower temperature. Slightly water soluble . Soluble in aqueous sodium hydroxide. Used medicinally as an expectorant. Used, because of its anti-oxidant properties, as an anti-skinning agent for paints.
Air & Water Reactions Sensitive to air and light (darkens). Slightly water soluble.
Reactivity Profile Guaiacol may react with oxidizing materials. Guaiacol forms salts readily with bases.
Fire Hazard Guaiacol is combustible.

 
Guaiacol Preparation Products And Raw materials
Raw materials 2-Nitrochlorobenzene-->o-Anisidine-->Pine oil-->CREOSOTE-->GUM GUAIAC
Preparation Products Vanillin-->Pyrocatechol-->Eugenol-->2,3-Dihydro-2,2-dimethyl-7-benzofuranol -->3-Hydroxy-4-methoxybenzaldehyde-->1,2-Dimethoxybenzene-->Guaifenesin-->Triclosan-->2-METHOXYPHENOXYACETIC ACID-->5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile-->3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile-->4-Bromo-2-methoxyphenol-->Homovanillic acid-->1-ALLYLOXY-2-METHOXY-BENZENE-->3,4-Dimethoxybenzyl chloride-->DL-4-HYDROXY-3-METHOXYMANDELIC ACID-->guacetisal -->Terpinyl cyclohexanol mixture-->Guaiacol glycidyl ether-->Sulfogaiacol