Horse chestnut extract

Product Description

Name: Horse chestnut extract
Synonyms: Aescin; Escin; (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid
Molecular Formula: C55H86O24
Molecular Weight: 1131.26
CAS Number: 6805-41-0
EINECS: 229-880-6
 
Aescin or escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum (the horse chestnut). Aescin is the main active compound in horse chestnut, and is responsible for most of horse chestnuts medicinal properties.
High-quality evidence suggests aescin is a safe and effective treatment for chronic venous insufficiency. In one randomized controlled trial, horse chestnut extract was found to be as effective and well-tolerated as use of compression stockings.
Aescin appears to produce effects through a wide range of mechanisms. Aescin induces endothelial nitric oxide synthesis by making endothelial cells more permeable to calcium ions, and also induces release of prostaglandin F2. Other possible mechanisms include serotonin antagonism and histamine antagonism and reduced catabolism of tissue mucopolysaccharides.